Vitamin A (Retinol acetate) (Vitamin A (Retinol acetate))

Vitamin A (Retinol acetate) (Vitamin A (Retinol acetate))

Release form, packaging and composition of the drug Vitamin A (Retinol acetate)

Capsules from light yellow to dark yellow, soft, gelatinous, spherical; filled with an oily liquid from light yellow to dark yellow, no rancid odor.

1 caps. retinol acetate (in terms of 100% vitamin A) 33,000 IU (11.35 mg)

Excipients: soybean oil up to 150 mg. Capsule shell: gelatin 31.04 mg, glycerol 9.76 mg, methyl parahydroxybenzoate 0.2 mg.

10 pieces. – contour cell packings. 10 pieces. – contour cell packaging (2) – cardboard packs. 10 pieces. – contour cell packaging (3) – cardboard packs. 10 pieces. – contour cell packaging (4) – cardboard packs.

10 pieces. – contour cell packs (10) – cardboard packs. 10 pieces. – contour cell packaging (50) – cardboard boxes. 10 pieces. – contour cell packaging (100) – cardboard boxes. 10 pieces. – contour cell packaging (200) – cardboard boxes. 10 pieces. – contour cell packaging (400) – cardboard boxes.

10 pieces. – contour cell packaging (600) – cardboard boxes.

pharmachologic effect.

Vitamin A belongs to the fat-soluble vitamins. It has a manifold effect on the vital activity of the organism. Plays an important role in redox processes (due to the large number of unsaturated bonds), participates in the synthesis of mucopolysaccharides, proteins, lipids. Retinol plays an important role in maintaining the normal state of the skin and epithelium of the mucous membranes, ensuring normal differentiation of epithelial tissue, in the processes of photoreception (contributes to human adaptation to darkness). Retinol is involved in mineral metabolism, cholesterol formation processes, enhances the production of lipase and trypsin, enhances myelopoiesis, cell division processes.

Local action is mediated by the presence of specific retinol-binding receptors on the surface of epithelial cells. Inhibits keratinization processes, enhances the proliferation of epithelial cells, rejuvenates cell populations and reduces the number of cells that follow the path of terminal differentiation.

Retinol is believed to have antineoplastic effects, which, however, does not apply to non-epithelial tumors.

Indications of the active substances of the drug Vitamin A (Retinol acetate)

Open the list of ICD-10 codes ICD-10 code Indication C80 Malignant neoplasm without specifying localization C95.9 Leukemia, unspecified E46 Protein-energy deficiency, unspecified E50 Vitamin A deficiency E55.0 Active rickets H01.1 Non-infectious dermatoses of the eyelids H04.1 Other diseases of the lacrimal gland (dry eye) H18.0 Pigmentation and corneal deposits H18.4 Corneal degeneration H35.5 Hereditary retinal dystrophies H53.1 Subjective visual disturbances J06.9 Acute upper respiratory tract infection, unspecified J42 Chronic bronchitis, unspecified J44 Other chronic obstructive pulmonary disease K25 Stomach ulcer K26 Duodenal ulcer K27 Peptic ulcer K29 Gastritis and duodenitis K52.9 Noninfectious gastroenteritis and colitis, unspecified K74 Fibrosis and cirrhosis of the liver L20.8 Other atopic dermatitis (neurodermatitis, eczema) L30.0 Monetoid eczema L30.0 Monetoid eczema L30.0 Monetoid eczema 40 L85.0 Acquired ichthyosis L85.1 Acquired keratosis [keratoderma] palmar-plantar L85.2 Keratosis punctate (palmar-plantar) N60 Benign breast dysplasia (incl. fibrocystic breast disease) T14.0 Superficial



trauma of an unspecified body region (including abrasion, bruising, contusion, hematoma, nonpoisonous insect bite) T14.1 Open wound of an unspecified body region T30 Thermal and chemical burns of an unspecified localization T33 Superficial frostbite.

Dosage regimen.

The dose is set individually, depending on the indications and the patient’s age..

Side effect.

Hypervitaminosis A: in adults – drowsiness, lethargy, headache, facial flushing, nausea, vomiting, gait disorders, soreness in the bones of the lower extremities; children may have fever, drowsiness, sweating, vomiting, skin rashes.

Possibly: increased cerebrospinal fluid pressure (hydrocephalus and protrusion of the fontanelle may develop in infants).

Contraindications for use.

Gallstone disease, chronic pancreatitis (exacerbation of the disease is possible), acute inflammatory skin diseases, pregnancy, breastfeeding, children under 7 years of age.

Nephritis, heart failure II-III degree, chronic alcoholism, liver cirrhosis, viral hepatitis, renal failure.

Application during pregnancy and lactation.

Application for violations of liver function.

Contraindicated for use in cholelithiasis.

With care: cirrhosis of the liver, viral hepatitis.

Application for impaired renal function.

Application in children.

Contraindicated for use in children under 7 years of age..

Use in elderly patients.

special instructions.

Use with caution in acute and chronic nephritis, with decompensation of cardiac activity.

Do not use more than 1 drug containing retinol at the same time to avoid overdose.

Drug interactions.

With simultaneous use with cholestyramine, colestipol, neomycin, a decrease in the absorption of retinol is possible.

Vitamin A is not recommended during long-term tetracyclines therapy due to the risk of intracranial hypertension.

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